Publications

List of recent publications


* LaVoy, E.C., Arlinghaus, K., Rooney, B., Gupta, P., Atkinson, R., and C. Johnston. High Adenovirus 36 seroprevalence among a population of Hispanic American youth. Int J Adolesc Med Health- in press

*Wardle, M.C., Lopez-Gamundi, P., and E.C. LaVoy. (2018) Effects of an acute bout of physical exercise on reward functioning in healthy adults. Physio and Behav 194:552-559.

# Rooney, B.V., Bigley, A., LaVoy, E., Laughlin, M., Pedlar, C., and R. J. Simpson. (2018) Lymphocytes and monocytes egress peripheral blood within minutes after cessation of steady state exercise: A detailed temporal analysis of leukocyte extravasation. Physio and Behav 194:260-267

#Lee, J., Lee, Y., LaVoy, E.C., Umetani, M., Hong, J. and Y. Park. (2018) Physical activity protects NLRP3 inflammasome-associated coronary vascular dysfunction in obese mice. Physiol. Reports 6(12):e13738.

*#Gupta, P., Bigley, A., Markofski, M., Laughlin, M., and E.C. LaVoy. (2018) Autologous serum collected 1h post-exercise enhances natural killer cell cytotoxicity. Brain Behav Immun. 71:81-92

# Serajian, A., Nourshahi, M., LaVoy, E., and D. Eliaspour. (2017) Decrease in baseline values of inflammatory mediators and improvement in muscular performance after 4-weeks fish oil supplementation. Razi Journal of Medical Sciences, 24 (160)

*LaVoy, E.C., Hussain, M., Reed, J. Kunz, H., Pistillo, M., Bigley, A. and R. J. Simpson. (2017) T-cell redeployment and intracellular cytokine expression following exercise: effects of exercise intensity and cytomegalovirus infection. Physiology Reports, 5 (1)

*LaVoy E.C., Fagundes C.P., and R. Dantzer. (2016) Exercise, inflammation, and fatigue in cancer survivors. Exercise Immunology Review, 22 82-93

Simpson, R.J., Bigley, A.B., Spielmann, G., E.C. LaVoy, Kunz, H., and C.M. Bollard. (2016) Human cytomegalovirus infection and the immune response to exercise. Exercise Immunology Review, 22 8-27.

# Silveira, S.L., LaVoy, E.C., and C.A. Johnston. (2016) Assisting the novice in lifestyle change. American Journal of Lifestyle Medicine, 10 (3)

*LaVoy E.C., Bollard C.M., Hanley P.J., Blaney J.W., O’Connor D.P., Bosch J.A., and R.J. Simpson. (2015) A single bout of dynamic exercise enhances the expansion of MAGE-A4 and PRAME-specific cytotoxic T-cells from healthy adults. Exercise Immunology Review, 21,144-53.

*LaVoy E.C., Bollard C.M., Hanley P.J., O’Connor D.P., Lowder T.W., Bosch J.A., and R.J. Simpson. (2015) A Single Bout of Dynamic Exercise by Healthy Adults Enhances the Generation of Monocyte-Derived-Dendritic Cells. Cellular Immunology 295, 52-59.

Brown, F.F., Bigley, A.B., Ross, J.S., LaVoy, E.C., Simpson, R.J., and S.D.R. Galloway. (2015) T-lymphocyte populations following a period of high volume training in female soccer players. Physiology and Behavior

*LaVoy, E.C., Bigley, A.B., Spielmann, G., Rector, J.L., Morrison, M.R., O’Connor, D.P. and R.J. Simpson. (2014) CMV amplifies T-cell redeployment to acute exercise independently of HSV-1 serostatus. Medicine and Science in Sports and Exercise, 46, 257-267.

Spielmann, G. Bollard, C.M., Bigley, A.B., Hanley, P.J., Blaney, J.W., LaVoy, E.C., Pircher, H. and R.J. Simpson. (2014) The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans. Brain Behavior and Immunity, 39, 142-151.

* denotes first/senior author, # denotes student manuscript

(selected publications. Full list in CV)
Graff RM, Kunz HE, Agha NH, Baker FL, Laughlin M, Bigley AB, Markofski MM, LaVoy EC, Katsanis E, Bond RA, Bollard CM, Simpson RJ. β2-Adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans. Brain Behav Immun. 2018 Aug 30. [Epub ahead of print] PMID: 30172948

Gupta P, Bigley AB, Markofski M, Laughlin M, LaVoy EC. Autologous serum collected 1 h post-exercise enhances natural killer cell cytotoxicity. Brain Behav Immun. 2018 Jul;71:81-92. PMID: 29656052

Hong J, Kim K, Park E, Lee J, Markofski MM, Marrelli SP, Park Y. Exercise ameliorates endoplasmic reticulum stress-mediated vascular dysfunction in mesenteric arteries in atherosclerosis. Sci Rep. 2018 May 21;8(1):7938. PMID: 29784903

Markofski MM, Jennings K, Timmerman KL, Dickinson JM, Fry CS, Borack MS, Reidy PT, Deer RR, Randolph A, Rasmussen BB, Volpi E. Effect of aerobic exercise training and essential amino acid supplementation for 24 weeks on physical function and muscle metabolism in healthy, independent older adults: a randomized clinical trial. J Gerontol Med Sci. Epub 2018 May 10. PMID: 29750251

Carrillo AE, Markofski MM, Flynn MG. Elevated inflammatory status and increased risk of chronic disease in chronological aging: Inflamm-aging or inflamm-inactivity? Aging and Disease. 2018 Dec; 9(6):xxx-xx

Agha NH, Baker FL, Kunz HE, Graff R, Azadan R, Dolan C, Laughlin MS, Hosing C, Markofski MM, Bond RA, Bollard CM, Simpson RJ. Vigorous exercise mobilizes CD34+ hematopoietic stem cells to peripheral blood via the β2-adrenergic receptor. Brain Behav Immun. 2018 Feb;68:66-75. Epub 2017 Oct 7. PMID: 29017969

Arlinghaus KR, Markofski MM, Johnston CA. Reducing anxiety to increase exercise in individuals with decreased lung capacity. Am J Lifestyle Med. 2017 April;11(4):307-309.

Reidy PT, Borack MS, Markofski MM, Dickinson JM, Fry CS, Deer RR, Volpi E, Rasmussen BB. Post-absorptive muscle protein turnover affects resistance training hypertrophy. Eur J Appl Physiol. 2017 May;117(5):853-866. PMID: 28280974

Borack MS, Reidy PT, Husaini SH, Markofski MM, Deer RR, Richison AB, Lambert BS, Cope MB, Mukherjea R, Jennings K, Volpi E, Rasmussen BB. Soy-Dairy Protein Blend or Whey Protein Isolate Ingestion Induces Similar Postexercise Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis Responses in Older Men. J Nutr. 2016 Dec; 146(12):2468-2475. PMID: 27798330

Reidy PT, Borack MS, Markofski MM, Dickinson JM, Deer RR, Husaini SH, Walker DK, Igbinigie S, Robertson SM, Cope MB, Mukherjea R, Hall-Porter JM, Jennings K, Volpi E, Rasmussen BB. Protein supplementation has minimal effect on muscle adaptations during resistance exercise training in young men: a double-blind randomized clinical trial. J Nutr. 2016 Sept; 146(9):1660-9. PMID: 27466602

Markofski MM, Dickinson JM, Drummond MJ, Fry CS, Fujita S, Gundermann DM, Glynn EL, Jennings K, Paddon-Jones D, Reidy PT, Sheffield-Moore M, Timmerman KL, Rasmussen, BB, and Volpi E. Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women. Exp Gerontol. 2015 May;65:1-7. PMID: 25735236

Timmerman KL, Amonette WE, Markofski MM, Ansinelli HA, Gleason EA, Rasmussen BB, and Mossberg KA. Impaired IL-6 and IL-10 response to exercise in patients with traumatic brain injury. Eur J Appl Physiol. 2015 Jan;115(1):111-8.

Markofski MM, Flynn MG, Carrillo AE, Armstrong C, Campbell WW, and Sedlock, DA. Exercise training-induced decrease in circulating inflammatory CD14+CD16+ monocyte percentage with and without weight loss in overweight and obese adults. Eur J Appl Physiol. 2014 Aug;114(8):1737-48.

Markofski MM and Braun WA. Influence of menstrual cycle on indices of contraction-induced muscle damage. J Strength Cond Res. 2014 Sep;28(9):2649.

Markofski MM, Carrillo AE, Timmerman KL, Jennings K, Coen PM, and Flynn MG. Exercise training modifies ghrelin and adiponectin concentrations and is related to inflammation in older adults. J Gerontol A Biol Sci Med Sci. 2014 Jun;69(6):675-81.

Drummond MJ, Timmerman KL, Markofski MM, Walker DK, Dickinson JM, Jamaluddin M, Brasier AR, Rasmussen BB, Volpi E. Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults. Am J Physiol Regul Integr Comp Physiol. 2013 Aug 1;305(3):R216-23.

Carrillo AE, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr. 2013 Jun;32(3):375-81

Drummond MJ, Dickinson JM, Fry CS, Walker DK, Gundermann DM, Reidy PT, Timmerman KL, Markofski MM, Paddon-Jones D, Rasmussen BB, Volpi E. Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1113-22.

Carrillo AE, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Vitamin D supplementation during exercise training does not alter inflammatory biomarkers in overweight and obese subjects. Eur J Appl Physiol. 2012 Aug;112(8):3045-52

Markofski MM and Volpi E. Protein metabolism in women and men: similarities and disparities. Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):93-7.

Coen PM, Flynn MG, Markofski MM, Pence BD, Hannemann RE. Adding exercise to rosuvastatin treatment: influence on C-reactive protein, monocyte toll-like receptor 4 expression, and inflammatory monocyte (CD14+CD16+) population. Metabolism. 2010 Dec;59(12):1775-83.

Lee J, Lee Y, LaVoy E, Umetani M, Hong J, *Park Y. Physical Activity Protects NLRP3 inflammasome-induced Vascular Dysfunction in Obesity. Physiol. Rep. 2018. Jun;6(12):e13738. doi: 10.14814/phy2.13738.

Hong J, Kim K, Park E, Lee J, Markofski MR, Marrelli SP, and *Park Y. Exercise ameliorates endoplasmic reticulum stress-mediated vascular dysfunction in atherosclerotic mesenteric arteries. Sci Rep. 2018 8:7938 | DOI:10.1038/s41598-018-26188-9. 2018

Lee J, Lee R, Hwang MH, Hamilton MT, *Park Y. The effects of exercise on vascular endothelial function in type 2 diabetes: A Systematic Review and Meta-analysis. Diabetol Metab Syndr. 2018 Mar 6;10:15. doi: 10.1186/s13098-018-0316-7. 2018

Lee J, Lee S, Zhang H, Hill MA, Zhang C, *Park Y. Interaction of IL-6 and TNF-α contributes to endothelial dysfunction in type 2 diabetic mice heart. PLoS ONE. 2017 Nov 2;12(11):e0187189. doi: 10.1371/journal.pone.0187189. 2017

Son Y, Kim K, Jeon S, Kang M, Lee S, *Park Y. Effect of exercise intervention on flow-mediated dilation in overweight and obese adults: Meta-analysis. Int J Vasc Med. 2017;7532702. doi: 10.1155/2017/7532702. 2017

So WY, Lee SY, Park Y, Seo DI. Effects of 4 weeks of horseback riding on anxiety, depression, and self-esteem in children with attention deficit hyperactivity disorder. J Mens Health. 2017– 13(2):e1-e7; September 28, 2017

Hong J, Kim K, Kim J, *Park Y. The role of endoplasmic reticulum stress in cardiovascular disease and exercise. Int J Vasc Med. 2017:2049217. doi: 10.1155/2017/2049217. 2017

Chen X, Zhang H, Hill MA, Zhang C, *Park Y. Regulation of coronary endothelial function affected by feedback among TNF-α, LOX-1 and adiponectin in ApoE knockout mice. J Vasc Res. 52(6):372-82. 2016

Kim JH and *Park Y. The combined effects of phytochemicals and exercise on fatty acid oxidation. J Exerc Nutrition Biochem. 20(4);20-26. 2016

Ghosh P, Behnke BJ, Stabley JN, Kilar CR, Park Y, Muller-Delp JM, Alwood JS, Shirazi-Fard Y, Schreurs NS, Globus RK, Delp MD. Effects of high-LET radiation and hindlimb unloading on skeletal muscle resistance artery vasomotor properties in mice. Radiation Research. Mar;185(3):257-66. 2016

Kunz H, Bishop NC, Spielmann G, Pistillo M, Reed J, Ograjsek T, Park Y, Mehta SK, Pierson DL, Simpson RJ. Fitness level impacts salivary antimicrobial protein responses to a single bout of cycling exercise. Eur J Appl Physiol. 115(5):1015-27. 2015

Park Y, Prisby RB, Lesniewski LA, Donato AJ, Delp MD. Effects of aging and exercise training on Angiotensin II-induced vasoconstriction of rat skeletal muscle arterioles, J Appl Phsiol., Oct;113(7):1091-100. 2012

*Park Y, Booth FW, Lee S, Laye MJ, and Zhang C. Physical activity opposes coronary vascular dysfunction induced during high fat feeding in mice. J Physiol (Lond). Sep;1;590(Pt 17):4255-68. 2012

Lee S, Park Y, Zhang C. exercise training prevents coronary endothelial dysfunction in type 2 diabetic mice. Am. J. Biomed. Sci 3(4): 241-252. 2011

Lee S, Park Y, Dellsperger KC, Zhang C. Exercise training improves endothelial function via adiponectin-dependent and independent pathways in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. Aug;301(2):H306-14. 2011

Park Y, Yang J, Zhang H, Chen X and Zhang C. Role of PAR2 in the regulation of TNF-α-induced endothelial dysfunction in type 2 diabetic mice. Basic Res Cardiol. Jan;106(1):111-23. 2011

Zhang H, Park Y, Liu Y and Zhang C. Coronary and aortic endothelial function affected by feedback between adiponectin and TNF-α in type 2 diabetic mice. Arterioscler Thromb Vasc Biol. Nov;30(11):2156-63. 2010

Yang J, Park Y, Zhang H, Gao X, Wilson E, Zimmer W, Abbott L and Zhang C. Role of MCP-1 in tumor necrosis factor alpha-induced endothelial dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 297(4):H1208-16. 2009

Yang J+, Park Y+, Zhang H, Xu X, Laine GA, Dellsperger KC and Zhang C (+Co-first authors). Feed-forward signaling of TNF-α and NFκB via IKKβ pathway induces insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 296(6):H1850-8, 2009

Park Y, Capobianco S, Gao X, Falck JR, Dellsperger KC and Zhang C. Role of EDHF in type 2 diabetes-induced endothelial dysfunction. Am J Physiol Heart Circ Physiol. 295(5):H1982-8, 2008

Zhang C, Park Y, Picchi A and Potter BJ. Maturation-induced endothelial dysfunction via vascular inflammation in diabetic mice. Basic Res Cardiol. 103(5):407-16. 2008

Gao X, Park Y, Capobianco S, Yang J, Zhang H, Picchi A and Zhang C.. Role of TNF alpha in prediabetic metabolic syndrome induced endothelial dysfunction. 8th World Congress for MICROCIRCULATION (Ed. Julian H Lombard). MEDIMOND S.r.l., International Proceedings., H815R9145: P179-185. 2007

Selected Funded Grants 
ACTIVE RESEARCH SUPPORT
External

NASA (NRA- NNJ16ZSA001N-SRHHC). Role: Co-Investigator (PI: Michael Delp). “Radiation, Simulated Weightlessness and Countermeasures: Effects on Cerebral and Coronary Vascular Function and Structure.” June 2018 – May 2021.

Korea Institute of Robot and Convergence (KIRO). Role: Co-Investigator (PI: Beom-Chan Lee). “Developing and Assessing Wearable Technologies to Predict and Prevent Falls.” June 2017 - December 2022.

American College of Sports Medicine (ACSM, Foundation Doctoral Student Research Grant) Role: Supervisor. (PI: Junyoung Hong, doctoral student). “The effect of exercise on purinergic receptor-mediated cerebrovascular dysfunction in Alzheimer’s Disease.”July 2018 – June 2019.

COMPLETED RESEARCH SUPPORT
External

CardioVascular Research Foundation. Role: Principal Investigator, “The Effect of Aerobic Exercise on Coronary Arterial Endothelial Function in ApoE-/- Mice – The Role of Liver X Receptor (LXR) and Uncoupling Protein-2 (UCP-2).” June 2015 – January 2017.

Simpson, R.J. Kunz, H., Agha, N. & R. Graff (2015). Exercise and the regulation of immune functions. Progress in Molecular Biology and Translational Science, 135, 355-380.

Fiuza-Luces, C., Simpson, R.J., Ramirez, M., Lucia, A., & N.A. Berger (2015). Physical function and quality of life in patients with chronic GvHD: a summary of preclinical and clinical studies and a call for exercise intervention trials in patients. Bone Marrow Transplantation. doi: 10.1038/bmt.2015.195

Brown F.F., Bigley A.B., Ross J.S., LaVoy E.C., Simpson R.J., & S.D.R. Galloway (2015). The response of T-lymphocyte populations to a period of high volume training in female soccer players. Physiology and Behavior, 152, 175-181.

Bigley, A.B. & R.J. Simpson (2015). NK-cells and Exercise: Implications for cancer immunotherapy and survivorship. Discovery Medicine, 19, 433-445.

Bigley, A.B., Spielmann, G., Agha, N., & R.J. Simpson (2015). The effects of age and latent cytomegalovirus infection on NK-cell phenotype and exercise responsiveness in man. Oxidative Medicine & Cellular Longevity [Epub: Article ID 979645].

Simpson, R.J. (2015) Fitness deficits in long-term ALL survivors. Blood, 125, 3366-3368.

LaVoy, E.C., C.M. Bollard, P.J. Hanley, D.P. O’Connor, T.W. Lowder, J.A. Bosch & R.J. Simpson (2015). A single bout of dynamic exercise enhances the generation of monocyte-derived dendritic cells. Cellular Immunology, 295, 52-59.

Bigley, A.B. Rezvani, K., Pistillo, M., Reed, J., Kunz, H., Agha, N., Bollard, C.M. & R.J. Simpson (In Press). Acute exercise preferentially mobilizes NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Part II: Impact of latent cytomegalovirus infection and catecholamine sensitivity. Brain, Behavior and Immunity, doi: 10.1016/j.bbi.2014

Ingram, L., R.J. Simpson, E. Malone & G. Florida-James (2015). Sleep disruption and its effect on lymphocyte redeployment following an acute bout of strenuous exercise. Brain, Behavior and Immunity, 47, 100-108.

LaVoy, E.C. C.M. Bollard, P.J. Hanley, J.W. Blaney, D.P. O’Connor J.A. Bosch & R.J. Simpson (2015). A single bout of dynamic exercise enhances the expansion of MAGE-A4 and PRAME-specific cytotoxic T-cells from healthy adults. Exercise Immunology Review, 21, 144-153.

Pollonini, L., Padhye, N., Re, R., Torricelli, A., Simpson, R.J. & C. Dacso (2015). Pulse transit time measured by photoplethysmography improves the accuracy of heart rate as a surrogate measure of cardiac output, stroke volume and oxygen uptake in response to graded exercise. Physiological Measurements, 36, 911-924

Fiuza-Luces, C., Garatachea, N., Simpson, R.J., Berger, N.A., Ramirez, M. & A. Lucia (2015) Understanding graft-versus-host disease: preliminary findings regarding the effects of exercise in affected patients. Exercise Immunology Review, 21, 80-112.

Kunz, H. Bishop, N.C., Spielmann, G., Pistillo, M., Reed, J., Ograjsek, T., Park, Y., Mehta, S., Pierson, D.L. & R.J. Simpson (2015) Fitness level impacts salivary antimicrobial responses to a single bout of cycling exercise. European Journal of Applied Physiology, 115, 1015-27

Simpson, R.J. and J.A. Bosch. (2014) Exercise immunology: perspectives on aging, health and extreme human performance. Brain, Behavior and Immunity, 39, 1-7. (editorial accompanying the special issue of the journal).

Spielmann, G. Bollard, C.M., Bigley, A.B., Hanley, P.J., Blaney, J.W., LaVoy, E.C., Pircher, H. & R.J. Simpson. (2014) The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans. Brain Behavior and Immunity, 39, 142-151.

Bigley, A.B., Rezvani, K., Chew, C., Sekine, T., Pistillo, M., Crucian, B., Bollard, C.M. and R.J. Simpson. (2014) Acute exercise preferentially mobilizes NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Brain, Behavior and Immunity, 39, 160-171.

Spielmann, G. Johnston, C.A., O’Connor, D.P., Foreyt, J.P. and R.J. Simpson. (2014) Excess body mass is associated with T-cell differentiation indicative of immune aging in children. Clinical and Experimental Immunology, 176, 246-254.

Crucian, B., Simpson, R.J., Mehta, S., Stowe, R., Chouker, A., Hwang, S., Actor, J.K., Salam, A.P., Pierson, D. and C. Sams. (2014) Terrestrial stress analogs for spaceflight associated immune system dysregulation. Brain, Behavior and Immunity, 39, 23-32.

Brown F.F., Bigley A.B., Sherry C., Neal C.M., Witard O.C., Simpson R.J. and Galloway S.D. (2014) Training status and sex influence on senescent T-lymphocyte redistribution in response to acute maximal exercise. Brain Behavior and Immunity, 39, 152-159.

LaVoy, E.C., Bigley, A.B., Spielmann, G., Rector, J.L., Morrison, M.R., O’Connor, D.P. and R.J. Simpson. (2014) CMV amplifies T-cell redeployment to acute exercise independently of HSV-1 serostatus. Medicine and Science in Sports and Exercise, 46, 257-267.

LaVoy, E.C., Nieman, D.C. Henson, D.A., Shanely, R.A., Knab, A.M., Cialdella-Kam, L. & R. J. Simpson. (2013) Latent cytomegalovirus infection does not alter innate immune function in response to a 75-km cycling time trial. European Journal of Applied Physiology, 113, 2629-2635.

Pistillo, M., Bigley, A.B., Spielmann, G., LaVoy, E.C., Morrison, M.R., Rahman, M. & R.J. Simpson. (2013) The effects of age and viral serology on gd T-cell numbers and exercise responsiveness in humans. Cellular Immunology, 284, 91-97.

Bigley, A.B., Spielmann, G., LaVoy, E.C. and R.J. Simpson. (2013) Can exercise-related improvements in immunity influence cancer incidence and prognosis in the elderly? Maturitas, 76, 51-56.

Mehta SK, Crucian BE, Stowe RP, Simpson RJ, Ott CM, Sams CF and Pierson DL. (2013) Reactivation of latent viruses is associated with increased plasma cytokines in astronauts. Cytokine, 61, 205-9.

Lavoy EC, Bosch JA, Lowder TW and Simpson RJ. (2013) Acute aerobic exercise in humans increases cytokine expression in CD27- but not CD27+ CD8+ T-cells. Brain, Behavior and Immunity, 27, 54-62.

Pollonini L, Re R, Simpson RJ, Dacso CC. (2012) Integrated device for the measurement of systemic and local oxygen transport during physical exercise. Engineering in Medical Biology Society, 37, 60-3.

Simpson, R.J., Lowder, T.W., Spielmann, G., Bigley, A.B., LaVoy, E.C. and Kunz, H. (2012) Exercise and the aging immune system. Ageing Research Reviews, 11, 404-20.

Bigley, A.B., Lowder, T.W., Spielmann, G., Rector, J. Pircher, H. and Simpson, R.J. (2012) NK-cells have an impaired response to acute exercise and a lower expression of the inhibitory receptors KLRG1 and CD158a in humans with latent cytomegalovirus infection. Brain, Behavior and Immunity, 26: 177-186.

Cosgrove C, Galloway SD, Neal C, Hunter AM, McFarlin BK, Spielmann G, and Simpson RJ. (2012) The impact of 6-month training preparation for an Ironman triathlon on the proportions of naive, memory and senescent T cells in resting blood. European Journal of Applied Physiology, 112, 2989-98.

LaVoy EC, McFarlin BK, Simpson RJ. (2011) Immune responses to exercising in a cold environment. Wilderness Environ Med, 22, 343-51.

Spielmann, G., McFarlin, B.K., O'Connor, D.P., Smith, P.J.W., Pircher, H. and Simpson, R.J. (2011) Aerobic fitness is associated with lower proportions of senescent blood T-cells in man. Brain, Behavior and Immunity, 25, 1521-9.

Simpson R.J. (2011) Aging, persistent viral infections and immunosenescence: can exercise "make space"? Exercise and Sports Science Reviews, 39, 23-33. (Invited Review).

Simpson, R.J., Cosgrove, C., Chee, M.M., McFarlin, B.K., Bartlett, D.B., Spielmann, G., O'Connor, D.P., Pircher, H and Shiels, P. (2010) Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans. Exercise Immunology Review, 16, 40-55.

Booth, S., Florida-James, G.D., McFarlin, B.K., Spielmann, G., O'Connor, D.P. and Simpson, R.J. (2010) The impact of acute strenuous exercise on TLR2, TLR4 and HLA.DR expression on human blood monocytes induced by autologous serum. European Journal of Applied Physiology, 110, 1259-1268.

Simpson, R.J. and Guy, K. (2010) Coupling aging immunity with a sedentary lifestyle: has the damage already been done? - A mini review. Gerontology, 56, 449-458. (Invited Review)

Simpson RJ, Graham SM, Florida-James GD, Connaboy C, Clement R, Jackson AS. (2010) Perceived exertion and heart rate models for estimating metabolic workload in elite British soldiers performing a backpack load-carriage task. Appl Physiol Nutr Metab, 35, 650-6.

Simpson, R.J., McFarlin, B.K., McSporran, C., Spielmann, G., Hartaigh, B.O. and Guy, K. (2009) Toll-like receptor expression on classic and pro-inflammatory blood monocytes after acute exercise in humans. Brain, Behavior and Immunity, 23, 232-239.

Simpson, R.J., Cosgrove, C., Ingram, L.A., Florida-James, G.D., Whyte, G.P., Pircher, H. and Guy, K. (2008) Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and old humans after exhaustive exercise. Brain, Behavior and Immunity, 22, 544-551.

Campbell, J.P., Guy, K., Cosgrove, C., Florida-James, G.D. and Simpson, R.J. (2008) Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise. Brain, Behavior and Immunity, 22, 375-380.

Simpson, R.J., Florida-James, G.D., Cosgrove, C., Whyte, G.P., Macrae, S., Pircher, H. and Guy, K. (2007) High-intensity exercise elicits the mobilization of senescent T-lymphocytes into the peripheral blood compartment in human subjects. Journal of Applied Physiology, 103, 396-401.

Simpson, R.J., Florida-James, G.D., Whyte, G.P., Middleton, N., Shave, R., George, K. and Guy, K. (2007) The effects of marathon running on expression of the complement regulatory proteins CD55 and CD59 on red blood cells, European Journal of Applied Physiology, 99, 201-204.

Simpson, R.J., Florida-James, G.D., Whyte, G.P., Black, J.R., Ross, J.A. and Guy, K. (2007) Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans. Research in Sports Medicine, 15, 157-174.

Simpson, R.J., Florida-James, G.D., Whyte, G.P. and Guy, K. (2006) The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (?2 integrin) and CD53. European Journal of Applied Physiology, 97, 109-121.

Simpson RJ, Gray SC, Florida-James GD. (2006) Physiological variables and performance markers of serving soldiers from two "elite" units of the British Army. J Sports Sci, 24, 597-604.

Simpson, R. J., M. R. Wilson, J. R. Black, J. A. Ross, G. P. Whyte, K. Guy & G. D. Florida-James (2005) Immune alterations, lipid peroxidation, and muscle damage following a hill race. Canadian Journal of Applied Physiology, 30, 196-211.



Published Book Chapters

Simpson, R.J. Kunz, H., Agha, N. & R. Graff (In Press) “Exercise and the regulation of immune function”. In: Progress in Molecular Biology Translational Science (PMBTS): Molecular and Cellular Regulation of Adaptation to Exercise (Editor: Bouchard, C), Elsevier, Oxford, UK.

Spielmann, G., Bigley, A.B., LaVoy, E.C. & R.J. Simpson (2013). “Aging Immunity and the Impact of Physical Exercise”. In: Immunology of Ageing. (Editors: Masoud, A. & Rezaei, N.) Springer, NY, USA.

Simpson, R.J. (2013) “Effects of Exercise on Blood Leukocyte Numbers”. In: Exercise Immunology (Editors: Gleeson, M. Bishop, N.C. and Walsh, N.) Routledge, Oxford, UK.

Simpson, R.J. (2012) "Immunosenescence". In: Encyclopedia of Exercise Medicine in Health and Disease. (Editor: Mooren, F.C.) Springer, NY, USA.

Simpson, R.J. & G. Spielmann (2012). Exercise and Immunosenescence. In: Immunosenescence: behavioural and psychosocial determinants. (Editors: Bosch, J.A., Phillips, A.C. and Lord J.M.) Springer, NY, USA.

Davison, G. & R.J. Simpson (2011). Immunity. In: Sport and Exercise Nutrition. (Editor: The Nutrition Society) Blackwell Publishing ltd., Cambridge, UK.